"Quantitative Microscopic Imaging and Genetics for Investigation of Neurodegeneration and Mental Disease" by Dr. Anna Devor

Recent developments in optical microscopy now offer a versatile suite of tools for high-resolution, high-sensitivity measurements of neuronal, vascular, and metabolic parameters in deep tissue and local, cell-type specific manipulations of neuronal activity. These technological advances have challenged the “too hard to do” status quo for mechanistic studies in vivo and have allowed a more holistic evaluation of neurological pathology in mouse models of human disease. Coupled with the advent of Genome Wide Association Studies and rapidly developing stem cell technology, microscopic imaging in vivo will play a central role for mechanistic investigation of neurodegeneration and mental disease.